Open AccessElectrospun polyurethane-based vascular grafts: physicochemical properties and functioning in vivo
Author(s) -
А. А. Гостев,
Vera S. Cherosova,
И. С. Мурашов,
David Sergeevichev,
Alexandr A Korobeinikov,
Alexandr M Karaskov,
А. А. Карпенко,
Pavel P. Laktionov
Publication year - 2019
Publication title -
biomedical materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 72
eISSN - 1748-605X
pISSN - 1748-6041
DOI - 10.1088/1748-605x/ab550c
Subject(s) - tec , materials science , vascular graft , neovascularization , electrospinning , polyurethane , biomedical engineering , in vivo , neointima , gelatin , layer (electronics) , composite material , angiogenesis , surgery , medicine , polymer , chemistry , cancer research , ionosphere , restenosis , biochemistry , physics , microbiology and biotechnology , astronomy , stent , biology
General physicochemical properties of the vascular grafts (VGs) produced from the solutions of Tecoflex (Tec) with gelatin (GL) and bivalirudin (BV) by electrospinning are studied. The electrospun VGs of Tec-GL-BV and expanded polytetrafluoroethylene (e-PTFE) implanted in the abdominal aorta of 36 Wistar rats have been observed over different time intervals up to 24 weeks. A comparison shows that 94.5% of the Tec-GL-BV VGs and only 66.6% of e-PTFE VGs ( р = 0.0438) are free of occlusions after a 6 month implantation. At the intermediate observation points, Tec-GL-BV VGs demonstrate severe neovascularization of the VG neoadventitial layer as compared with e-PTFE grafts. A histological examination demonstrates a small thickness of the neointima layer and a low level of calcification in Tec-GL-BV VGs as compared with the control grafts. Thus, polyurethane-based protein-enriched VGs have certain advantages over e-PTFE VGs, suggesting their utility in clinical studies.