Open AccessScaling Theory for Driven Polymer Translocation through a Double Nanopore
Author(s) -
Aniket Bhattacharya
Publication year - 2022
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2241/1/012002
Subject(s) - nanopore , scaling , statistical physics , scaling limit , first hitting time model , brownian dynamics , limit (mathematics) , chain (unit) , ansatz , biological system , materials science , physics , brownian motion , chemical physics , nanotechnology , mathematics , mathematical analysis , quantum mechanics , geometry , biology
We study DNA translocation through a double nanopore system subject to a net bias using Brownian dynamics simulation on a model system. We consider the limit d LR < < L, where d LR is the distance between the pores and L = Nσ is the contour length of the chain consisting of N monomers of diameter σ . In this limit, we generalize a scaling ansatz for the mean first passage time, originally proposed for the driven translocation through a single nanopore, for the double nanopore system and demonstrate its validity using simulation data. The simulation data enables us to extract the pore friction as a function of the chain stiffness. The method can be used to determine the mean first passage time 〈 τ 〉 for longer chains difficult to extract from BD simulation.