Open AccessDevelopment of dosimetric procedures for experimental ultra-high dose rate irradiation at a clinical linear accelerator
Author(s) -
Elise Konradsson,
Kristoffer Petersson,
Gabriel Adrian,
Michael Lempart,
Börje Blad,
Sofie Ceberg,
Tommy Knöös,
Sven Bäck,
Crister Ceberg
Publication year - 2022
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2167/1/012003
Subject(s) - ionization chamber , linear particle accelerator , dosimeter , irradiation , dosimetry , collimator , dose rate , dose profile , materials science , nuclear medicine , imaging phantom , thermoluminescent dosimeter , medical physics , ionization , beam (structure) , optics , ion , physics , medicine , nuclear physics , quantum mechanics
As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish embryos and small animals using a 10 MeV electron beam at a modified clinical linear accelerator, and describe the dosimetric steps required to initiate clinical trials. The dosimetric equipment used for our pre-clinical experiments consisted of radiochromic film, thermoluminescent dosimeters, a Farmer-type ionization chamber and phantom material mimicking the experimental setup for irradiation. In preparation for small animal irradiation, dose profiles and depth dose curves were measured for all collimator sizes. The average dose rates were ≥620 Gy/s, ≥640 Gy/s and ≥400 Gy/s for cells, zebrafish embryos and small animals, respectively.