Open AccessProtein secondary structure analysis of serum from patients with oncohematological diseases
Author(s) -
E S Mikhailets,
Д А Чернышев,
E. A. Telnaya,
Л.В. Плотникова,
А Д Гарифуллин,
Alexey Kuvshinov,
Sergey Voloshin,
A. M. Polyanichko
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2103/1/012053
Subject(s) - multiple myeloma , chronic lymphocytic leukemia , leukemia , medicine , blood proteins , immunology
One of the promising approaches for diagnosing oncohematological diseases is infrared spectroscopy of blood serum. In this work secondary structure of blood serum proteins of patients with multiple myeloma, chronic lymphocytic leukemia and healthy donors was studied using IR spectroscopy. As a result of the study, it was found that the secondary structure of blood serum proteins in patients with chronic lymphocytic leukemia does not change in comparison with healthy donors. In contrast, patients with multiple myeloma have significant differences in the secondary structure composition of serum proteins compared to healthy donors. We conclude, that IR spectroscopy makes it possible to distinguish serum of healthy donors and patients with multiple myeloma, leading to the potential applicability of this approach to the diagnosis of multiple myeloma.