Open AccessCombination of cytostatic chemotherapy with cisplatin and photodynamic therapy with Radachlorin reduced resistance of K562 and Hela cell lines
Author(s) -
В. В. Клименко,
Stanislav V. Shmakov,
N Knyazev,
Н. А. Верлов,
А. А. Богданов,
Ivan Terterov,
А. А. Богданов
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2086/1/012125
Subject(s) - hela , cisplatin , photodynamic therapy , k562 cells , apoptosis , cancer research , combination therapy , chemotherapy , cytotoxicity , leukemia , cervical carcinoma , cell culture , cell cycle , cell , medicine , chemistry , oncology , pharmacology , in vitro , biology , cancer , biochemistry , cervical cancer , organic chemistry , genetics
In this work were study combination effect of photodynamic therapy and cisplatin on the proliferation activity of K562 human leukemia cells and Hela cervical carcinoma cells. A decrease in cell viability and an increase the fraction of apoptotic cells for combination treatment compared with single therapy were observed. It has been shown that the G2/M-phase of cell cycle decreases compared with cisplatin treatment alone, which demonstrates an increase anti-proliferative effect. The combination index of the photodynamic therapy with Radachlorin and cisplatin was calculated and indicates a synergistic effect.