Open AccessComputational modeling of schedule-specific chemotherapy outcomes in mouse tumor model
Author(s) -
Ivan Terterov,
Vyacheslav A. Chubenko,
N Knyazev,
В. В. Клименко,
А. А. Богданов,
Vladimir Moiseyenko,
А. А. Богданов
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2086/1/012122
Subject(s) - drug administration , schedule , cancer chemotherapy , pharmacodynamics , chemotherapy , pharmacokinetics , computer science , drug , scheduling (production processes) , medicine , intensive care medicine , pharmacology , mathematical optimization , mathematics , operating system
Despite the rapid development of new innovative strategies in cancer treatment like immunotherapy, chemotherapy still remains a common choice in many cases. Standard protocols of chemotherapeutic administration rely on a maximal tolerated dose paradigm, however there is growing evidence that this approach is not always optimal. Alternative scheduling, like metronomic - low dose continuous drug administration - were recently proved their efficacy. The space of available variants of drug administration protocols is prohibitively large to be explored empirically, and there is an urgent need of predictive mathematical models for rational chemotherapeutic scheduling design. In this work we tested the ability of the minimal pharmacokinetic-pharmacodynamics model to describe schedule-specific tumor volume time evolution in different mouse tumor models.