Open AccessModel of ‘implant-host’ neural circuits in a microfluidic chip in vitro
Author(s) -
В. И. Колпаков,
Y. Pigareva,
Arseniy Gladkov,
Anton Bukatin,
Victor B. Kazantsev,
И.В. Мухина,
Alexey Pimashkin
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2086/1/012111
Subject(s) - microfluidics , modular design , chip , microfluidic chip , biological neural network , plating (geology) , scaffold , nanotechnology , materials science , computer science , biomedical engineering , engineering , biology , telecommunications , paleontology , operating system , machine learning
In this study, we developed a new model of neuronal cells plating into a developed neural network to study functional integration using microfluidic methods. The integration was modeled in a three-chamber microfluidic chip by growing two weakly coupled neuronal networks and enhancing its connectivity by plating new dissociated cells. The direction of connections was formed by the asymmetric design of the chip. Such technology can be used to develop a new type of scaffold to recover the modular structure of the network.