Open AccessThe influence of temperature on biodistribution of N,N,N’,N’- ethylenediaminetetrakis(methylene phosphonic) acid labeled with gallium-68
Author(s) -
В. К. Тищенко,
В. М. Петриев,
E. D. Stepchenkova,
П. В. Шегай,
St. A. Ivanov,
А. Д. Каприн
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2058/1/012042
Subject(s) - biodistribution , gallium , radiochemistry , nuclear medicine , chemistry , tibia , positron emission tomography , nuclear chemistry , medicine , biochemistry , in vitro , surgery , organic chemistry
Bone metastases are serious complication in the progression of various types of cancer. It determines the requirement of modern nuclear diagnostic tools, including positron emission tomography (PET). In this study the biodistribution of EDTMP labeled with gallium-68 ( 68 Ga-EDTMP) prepared at different temperature (20, 50, and 95 °C) was investigated. All experimental studies were performed in healthy intact Wistar rats by measuring the radioactivity in organs and tissues with gamma counter. All 68 Ga-EDTMP formulations accumulated predominantly in bones. Only in tibia the uptake of 68 Ga-EDTMP prepared at 95 °C was higher (p < 0.05) than 68 Ga-EDTMP prepared at 20 °C, but in other bones there weren’t any statistical differences in uptake of 68 Ga-EDTMP formulations. The amounts of 68 Ga-EDTMP formulations in soft organs and tissues were lower when compared with bones. In conclusion, a temperature of reaction mixture had an influence on the biodistribution of 68 Ga-EDTMP in bones.