Open AccessInvestigation of the phenomenon of photobleaching and evaluation of the effectiveness of treatment using a led photodynamic therapy device on optical phantoms
Author(s) -
Denis A. Glechik,
Victor B. Loschenov
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2058/1/012034
Subject(s) - photodynamic therapy , photobleaching , photosensitizer , protoporphyrin ix , cancer therapy , fluorescence , medicine , materials science , optoelectronics , optics , cancer , biomedical engineering , chemistry , photochemistry , physics , organic chemistry
The mortality rate from various oncological diseases remains consistently extremely high, even in spite of recent breakthrough discoveries in the field of cancer therapy [1-3]. One of the most promising cancer treatments is photodynamic therapy (PDT) combined with fluorescence diagnostics (FD) [4, 5]. This study aims to evaluate the efficiency of the PDT procedure using an experimental LED device for photodynamic therapy and fluorescence diagnostics of neoplasms by the level of photobleaching of the photosensitizer protoporphyrin IX (PPIX) in optical phantoms of the skin. The results of spectral measurements showed that the LEDs is able to effectively induce oxidative stress in cancer cells, and due to the presence of a video system, it becomes possible to register the level of tissue fluorescence.