Open AccessCreation of an MRI phantom based on super-paramagnetic nanoparticles of iron oxide (SPIO) for standardization of the conversion of T2 * values in the concentration of iron in the liver
Author(s) -
P.A. Bulanov,
E.E. Nazarova,
P.E. Menshchikov,
D.A Kupriyanov,
Г. В. Терещенко,
Galiovichkova
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/2015/1/012025
Subject(s) - imaging phantom , reproducibility , repeatability , iron oxide , homogeneity (statistics) , paramagnetism , materials science , iron oxide nanoparticles , nanoparticle , biomedical engineering , nuclear medicine , nuclear magnetic resonance , chemistry , medicine , nanotechnology , mathematics , chromatography , physics , statistics , metallurgy , quantum mechanics
In this study the standardization method for T2* maps acquisition on various MR scanners (3T and 1.5T) is proposed. The reproducibility of the obtained T2* values is realized through the MR-compatible phantom containing paramagnetic complex iron oxide nanoparticles. The repeatability of measurements results has shown that the created phantom retains all the required characteristics (homogeneity, stability of concentrations and manifested paramagnetic properties) over a long period of time. The application of standardized T2* values allows to use previously received T2*, [ms] to iron concentrations in the dry substance of the liver (LIC), [mg/ml] conversion formulas for accurate, fast and non-invasive MRI diagnostics of liver iron overload.