Open AccessThe Efficacy and Safety of Wuling Powder on Cirrhotic Ascites: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Author(s) -
Zhanke Chen,
Xiaodong Zhang,
Feng Shao,
Bing Li,
Huan Li,
Kang Zhang,
Jiangyan Xu
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1992/4/042040
Subject(s) - ascites , medicine , cochrane library , meta analysis , randomized controlled trial , adverse effect , incidence (geometry) , gastroenterology , liver function , physics , optics
Objective To evaluate the efficacy and safety in patients with cirrhotic ascites treated by Wuling Powder. Methods PubMed, Web of science, The Cochrane library, EMbase, CNKI, WAFANG, VIP and SinoMed database were searched. Randomized controlled studies of cirrhotic ascites were collected from the establishment of the database to February 20, 2020. EndNote was used for literature screening, RevMan 5.3 was used for data analysis, GRADEpro was used to evaluate the evidence quality. Results 11 studies with 1054 patients were analyzed, Meta-analysis: @@@2460;Total effective rate: The Wuling powder group was higher (P 0.05). @@@2463; Recurrence rate: The Wuling powder group was lower (P <0.01). @@@2464; GRADE evaluation: The quality of evidence in the total effective rate, ALB index and incidence of adverse reactions was intermediate, the others were low or very low. Conclusions The Wuling powder combined with basic western medical treatment for cirrhotic ascites can significantly improve clinical efficiency, liver function and reduce recurrence rate, the adverse events were not obvious. However, due to the low quality of the included studies, it should be used with caution in the clinic.