Open AccessInnovative miniaturized approach by MicroNIR and chemometrics for the monitoring of the occupational exposure of workers
Author(s) -
Giuseppina Gullifa,
Roberta Risoluti
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1960/1/012008
Subject(s) - chemometrics , calibration , cladribine , process engineering , computer science , chromatography , biochemical engineering , data mining , chemistry , engineering , statistics , mathematics , medicine
The study focuses on the monitoring of the cladribine exposure during production of pharmaceutical ingredients by a novel first level test based on microNIR spectroscopy for the monitoring of the worker’s exposure to drugs. The method permits to perform the analyses directly onsite and online as it is portable and miniaturized and record data in wireless mode. The calibration of the response was performed by considering filter membrane fortified with increasing amount of cladribine to reproduce real samples. All the signals were processed by chemometrics and a model of prediction was finally developed to predict unknown samples. Gas chromatography was used to compare the results from a reference technique with the ones from the novel method, obtaining a satisfactory correlation of 0.9989.