Open AccessElectron-deficient N-oxyl radicals – new reagents for selective oxidative functionalization of organic substrates
Author(s) -
Igor B. Krylov,
Alexander S. Budnikov,
Elena R. Lopat’eva,
Oleg O. Segida,
Stanislav A. Paveliev,
Alexander O. Terent’ev
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1942/1/012007
Subject(s) - radical , reagent , surface modification , chemistry , photochemistry , organic synthesis , oxidative coupling of methane , oxidative phosphorylation , polymerization , combinatorial chemistry , organic chemistry , catalysis , polymer , biochemistry
N -oxyl radicals are well known as one of the richest classes of long-living free radicals. They are widely used as redox catalysts, mediators of living polymerization, contrast reagents for tomography applications, spin labels for biomacromolecule studies, components of organic batteries and magnetic materials. In the last decade, less stable but more reactive electron-deficient N -oxyl radicals have been harnessed as reagents for oxidative functionalization of organic substrates via selective C-H bond cleavage or radical addition to C = C bonds. Wide array of C-O coupling products can be achieved employing N -oxyl radicals as O-reagents for oxidative C-O coupling. Selected examples of methods for oxidative functionalization of organic substrates by N -oxyl radicals developed in our group are summarized in the present paper.