Open AccessStudy of antiinflamation activity in ethanol extract from coriander leaf (coriandrum sativum l.) induced by carrageenan in male rats
Author(s) -
Siti Morin Sinaga,
M. Rian Ramadhan Batubara,
Marah Halim Pulungan,
Henni Cintya,
H Dhermawan
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1940/1/012066
Subject(s) - coriandrum , carrageenan , sativum , diclofenac sodium , traditional medicine , positive control , diclofenac , chemistry , anti inflammatory , pharmacology , ethanol , medicine , botany , biology , biochemistry
Coriander ( Coriandrum sativum L.) is a popular spice plant in Indonesia. This plant has benefits as traditional herbal medicine plants, especially in the leafy part of which are useful as anti-inflammatory. The objective of this research is to determine the anti-inflammatory effects of ethanol extract of coriander leaves on the soles of male rats induced by λ-carrageenan. The method used in this study is the paw edema method using a digital plethysmometer with the principle of measurement based on Archimedes’ law and carried out experimentally by dividing 25 mice into 5 groups. Group 1, 2, and 3 were given ethanol extract of coriander leaves (EECL) with each doses of 100, 200, and 400 mg/kgbw, group 4 as negative control, group 5 as positive control given diclofenac sodium, then the volume is measured. The results of this study from tukey test results on inflammation showed that EECL doses of 100, 200, and 400 mg/kgbw didn’t differ significantly (p> 0.05) with diclofenac sodium dose of 2.25 mg/kgbw at 240 minutes to 360 minutes, but significantly different from CMC Na 0.05% (p 0.05) with diclofenac sodium dose of 2.25 mg/kgbw at 30 minutes to 360 minutes. The Conclusion of this study is EECL doses of 100, 200, and 400 mg/kgbw have anti-inflammatory activity in carrageenan-induced male rats. EECL dose of 400 mg/kgbw has the best average inflammation inhibitory activity.