Open AccessLiterature Review on Estimation of Drug Parameters Using Physiologically-Based Pharmacokinetic Modeling
Author(s) -
B. Ambikadevi,
P. Subha Hency Jose
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1937/1/012025
Subject(s) - physiologically based pharmacokinetic modelling , bioavailability , pharmacokinetics , drug , pharmacology , plasma concentration , chemistry , biochemical engineering , medicine , engineering
Physiologically based pharmacokinetic (PBPK) modelling is a computing technique used to identify the pharmacokinetic properties of humans and other animal species. This technique is used to identify various drug parameters. One of the parameters is bioavailability. Bioavailability is defined as the fraction of substances being absorbed by the body. Contrasts in bioavailability, realizing whether drug formulations are identical is necessary. The area under the plasma concentration time curve which is AUC determines the bioavailability of the drug. PBPK model is a significant modelling to determine the pharmacokinetic parameters. The goal of this paper is to review various literature which uses PBPK model in different pharmaceutical applications in different populations evaluating, verifying, predicting and identifying different pharmacokinetic and drug parameters.