The synthesis results comparison of spirooxindole derivatives using TiO2 and TiO2/SiO2 catalyst

Derivatives of Spirooxindole compounds with the peculiarities of a heterocylic ring-shaped framework, therefore these compounds have biological activities that play an important role in the pharmaceutical field. The synthesis of spirooxindole derivates was successfully carried out with the Multicomponent reaction that plays a role in it is the Knovenagel condensation reaction and followed by Michael’s addition reaction. The derivative reaction of spirooxindole compounds is more effective and efficient in synthesis time because the reaction uses a heterogeneous catalyst of TiO 2 /SiO 2 nanoparticles. In this research we will compare using TiO 2 and nano TiO 2 /SiO 2 as catalyst. This study produced a spirooxindole compound derivative using precursors such as, isatin, malononitrile and 1,3-diketone groups varied with baribituric acid. The results of the reaction optimization obtained that reaction time of 60 minutes, at temperature of 50 ° C, and a catalyst load of 12.5%. The yield percentage obtained under optimum conditions was found 82,72% in TiO 2 catalyst and then 86, 81% in TiO 2 /SiO 2 catalyst. The yield was obtained after the compound was recrystallized using hot ethanol. The characterization of TiO 2 and TiO 2 /SiO 2 catalysts was confirmed using FT-IR, XRD, and SEM-EDX. While the characterization of the spirooxindole compound derivate products was confirmed by TLC, FT-IR, and UV-Vis.