Open AccessDevelopment of a module for an automated diagnostic system for antibodies G and M
Author(s) -
Т. Г. Середа,
С. Н. Костарев,
O. V. Kochetova
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1889/5/052019
Subject(s) - asymptomatic , antibody , immune system , virus , immunology , medicine , disease , virology , pathology
The infectious disease COVID-19 occurs as a result of infection with the SARS-CoV-2 coronavirusstrain. Most often, COVID-19 proceeds with signs of an acute respiratory viral infection (ARVI) (fever, cough, body aches); loss of smell, nausea, and shortness of breath are possible. However, in a large percentage of those infected, the course of the disease is asymptomatic. After the virus entry into the body, the immune system begins to produce antibodies specific to this virus (Ig - immunoglobulins) - an important factor in the formation of the immune system’s defense against infection. Antibody testing is recommended as an additional method for diagnosing an acute infection or when it is impossible to study smears by amplification of nucleic acids, to identify individuals with an asymptomatic form of infection, to establish the fact of a previous infection, and also to select potential donors of immunocompetent plasma. Determination of antibodies of different classes in the blood is informative evidence of the current or past infectious process and helps to identify the stage of the infection development. More often, the level of antibodies of class M (IgM) and G (IgG) is determined in the blood. The development of the instrument base of express analyzers for monitoring the presence of antibodies to the new coronavirus infection COVID-19 is currently relevant in connection with the emerging and ongoing pandemic. It is possible to use the following systems as test analyzers for immune enzyme medium: ARCHITECT – IgG, Abbott and ELISA-IgM-BEST. For the hardware, an Omron industrial controller and CX-One programming system can be used. The truth table for the formation of signals on the diagnosis of the disease has been developed to obtain logical equations for the operation of the analyzer module. The synthesis of relay-contact circuits has been carried out. The simulation of the module’s operation showed satisfactory results. Timely and correct diagnostic measures make it possible to diagnose and assess the severity of the disease as early as possible.