Open AccessDesign, Synthesis and Biological Screening of New Benzimidazole Derivatives
Author(s) -
Ali Mohammed Sabur,
Muayad Ahmed Rdaiaan
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1879/2/022056
Subject(s) - benzimidazole , bacillus subtilis , acinetobacter baumannii , antibacterial activity , ciprofloxacin , staphylococcus aureus , chemistry , pseudomonas aeruginosa , bacteria , microbiology and biotechnology , combinatorial chemistry , stereochemistry , biology , organic chemistry , antibiotics , genetics
In this study, we synthesized a series of benzimidazole compounds containing. 1,3,4-thiadiazole ring from many reaction steps. The obtained benzimidazole series were characterized by melting point, Data from FT-IR and 1H-13C-NMR and In vitro screening of antibacterial activity against strains of selected pathogenic Gram-positive ( Staphylococcus aureus, Bacillus subtilis ) and Gram-negative ( Acinetobacter baumannii, Pseudomonas aeruginosa ) bacteria relative to (Amoxicillin) and (Ciprofloxacin) as standard antibacterial agents has shown high pharmacological activity.