Open AccessPhysiological and histological protective role of Astragalus spinosus root alcoholic extract against oxidative stress induced by H2O2 in rabbits
Author(s) -
Moafaq Mutlak Zeidan,
Qussay Noori Raddam
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1879/2/022039
Subject(s) - oxidative stress , astragalus , creatinine , zoology , hydrogen peroxide , body weight , chemistry , medicine , biology , biochemistry , pathology , traditional chinese medicine , alternative medicine
This study amid to evaluate the role of plant’s root ( Astragalus spinosus ), in biochemical parameters and histological sections effect in reduce the oxidative stress induced by hydrogen peroxide in rabbits Oryctalagus cuniculus , 7-9 months age and (1300-1500 g) of weight. Animals were distributed to three groups, every group were included five rabbits; group (1) control received water and diet. Group (2): animals treated with H2O2 (0.05) and drinking water. Group (3): animals treated with H2O2 and alcoholic extract of the plant root (5mg/kg body weight) for period one month. Study showed high significant increasing in Creatinine and ALP, LDH concentrations of animals treated with H2O2 alone (1.74±0.40) (9.900±1.058), (260.40±26.66) respectively, in compared with control (0.838±0.08) (8.420±1.132), (154.0±49.79) respectively while the concentration of Creatinine, ALP and LDH had been decreased with high significant (P≤ 0.05) in group treated with H2O2 and extract of the plant roots (0.79±0.09), (9.220±0.801) and (166.2±36.08) respectively in compared with H2O2 group. And the result of histological sections of liver, kidneys and heart, which showed an improvement of cells in group treated with the extract of the plant which had been induced by oxidative stress.