The Effectiveness Extract of Curcuma Xanthorriza Roxb to Decrease Histopathology Brain Pressure in Male Mice (Mus Musculus)

This study was to determine the effect of Curcuma extract on brain histopathology in hypertensive-induced male mice compared with captopril administration. Curcuma was extracted using remaseration method using 96% ethanol solvent. Induction of hypertension using L-name for 4 weeks where the first 2 weeks are given before therapy then the next 2 weeks are given with therapy. The therapy used is curcuma extract and captopril as control therapy. This study used four groups of mice that group distilled water, L-Name, captopril and curcumin with the average yield is 42 ± 11.81, 57.51 ± 166, 119 ± 8.40, and 111.5 ± 14.20. Results of analysis using Tukey’s Post Hoc test showed that there was no significant difference between groups aquades, captopril, and extract Curcuma xanthorriza but there are significant differences between the groups of L-Name with the other three groups. It can be concluded that captopril can reduce the amount of damage to brain cells in male mice but not as good as Curcuma xanthorriza extract.