Open AccessMicro-mechanism of low-density lipoproteins (LDL) transport in multi-layered arterial wall
Author(s) -
Erhui Wang,
Xuelan Zhang,
Kheder Suleiman,
Chang Shu,
Liancun Zheng
Publication year - 2021
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1748/4/042022
Subject(s) - arterial wall , vascular wall , consistency (knowledge bases) , mechanism (biology) , materials science , reliability (semiconductor) , viscosity , mechanics , layer (electronics) , coupling (piping) , biophysics , nanotechnology , computer science , composite material , physics , cardiology , thermodynamics , medicine , quantum mechanics , artificial intelligence , power (physics) , biology
This paper investigates micro-mechanism of LDL transport numerically in a multi-layer arterial wall. A novel comprehensive 3D model is developed by considering the coupling interactions between vascular layers, and numerical simulations are carried out for a two-layer structure arterial wall. Results displayed the effects of dynamic viscosity on LDL transport. Moreover, we present data demonstrating that endothelial cells have a great blocking effect on the permeation and transmission of macromolecules by the different vascular wall. Furthermore, to verify the reliability and efficiency, a comparison is presented which shows that our numerical results are in good consistency with the experimental data in the literature.