Open AccessInteraction of HMGB-domain proteins from differentiated cells with DNA modified by cisplatin
Author(s) -
Е. В. Чихиржина,
T. Yu. Starkova,
A. M. Polyanichko
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1697/1/012046
Subject(s) - circular dichroism , dna , cisplatin , chemistry , supramolecular chemistry , platinum , absorption (acoustics) , biophysics , microbiology and biotechnology , biochemistry , biology , crystallography , genetics , materials science , chemotherapy , crystal structure , composite material , catalysis
Using UV absorption spectroscopy and circular dichroism, we studied the interaction of DNA-cisplatin complexes with nonhistone chromosomal proteins HMGB1 and HMGB2. It was shown that the presence of platinum ions affected the ability of HMGB2 to form large supramolecular complexes with DNA. The role of C-terminal domain of the HMGB1/2 proteins is discussed.