Open AccessSynthesis, Characterization and Study of some of New Mefenamic Acid Derivatives as cytotoxic Agents
Author(s) -
Iman Assim Mohammed,
Mohanad Mousa Kareem
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1664/1/012081
Subject(s) - mefenamic acid , chemistry , amide , cytotoxicity , in vitro , carbon 13 nmr , combinatorial chemistry , derivative (finance) , stereochemistry , organic chemistry , chromatography , biochemistry , economics , financial economics
A new system drugs derivative was designed from Mefenamic Acid. These derivatives have been synthesized by reaction between mefenamic acid and different amino drugs via amide group. A number of compounds based on this new scaffold were prepared in good yields. These compounds have been purified and followed using TLC to determine purity with R f value. All synthesized compounds structures were confirmed by 1 H-NMR, 13 CNMR and FTIR techniques. All compounds were evaluated for their anticancer and anti-bacterial activities. Some of the compounds synthesized showed cytotoxic activities in vitro. Most of synthesized compounds induced significant reduction in the cytotoxic response as compared with controls.