Open AccessBiological washout effect in in-beam PET: animal studies
Author(s) -
Chie Toramatsu,
Akram Mohammadi,
Hidekazu Wakizaka,
Chie Seki,
Fumihiko Nishikido,
Shuichi Sato,
Iwao Kanno,
Miwako Takahashi,
Kumiko Karasawa,
Yoshiyuki Hirano,
Taiga Yamaya
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1662/1/012032
Subject(s) - washout , positron emission tomography , efflux , chemistry , positron , nuclear medicine , in vivo , radiochemistry , irradiation , biophysics , physics , medicine , biochemistry , biology , nuclear physics , microbiology and biotechnology , electron
Positron emission tomography (PET) is a practical tool for range verification of hadron therapy. As well, the quantitative washout of the positron emitters has a potential usefulness as a diagnostic index, but the modelling for this has not been established. In this study, we measured washout rates of rabbit brain and performed kinetic analysis to explore the washout mechanism. Six rabbit brains were irradiated by 11 C and 15 O ion beams, and dynamic PET scan was performed using our original depth of interest (DOI)-PET prototype. The washout rate was obtained based on the two-compartment model, where efflux from tissue to blood (k 2 ), influx (k 3 ) and efflux (k 4 ) from the first to second compartments in tissue were evaluated. The observed k 2 , k 3 and k 4 of 11 C were 0.086, 0.137 and 0.007 min −1 , and those of 15 O were 0.502, 0.360 and 0.007 min −1 , respectively. It was suggested permeability of a molecule containing 11 C atoms might be regulated by a transporter. The k 2 of 15 O was comparable with 15 O-water. This study provides basic data for modelling of the washout effect.