Open AccessElectrochemical Biosensors for Determination of Anticancer Medicine Etoposide in Human Blood by Glassy Carbon Modified Electrode Based on Film of Poly (L-Lysine) with MWCNTS
Author(s) -
Mohammed I. Majeed,
Eman A. M. Al-Jawadi
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1660/1/012092
Subject(s) - electrochemistry , biosensor , materials science , cyclic voltammetry , electrode , electrochemical gas sensor , glassy carbon , detection limit , etoposide , carbon nanotube , nanotechnology , chromatography , chemistry , medicine , surgery , chemotherapy
Sensitive, selective and reproducible electrochemical sensors were developed for the electroanalysis of Etoposide (anticancer drug) based on L-lysine film, using the PLY-MWCNTS/GCE sensor. The PLY-MWCNTSs films on modified electrode exhibited very good conductivity. Cyclic voltammetry (CV) was applied to examine the electrochemical behavior of PLY film and electrochemical response toward ETO. The PLY-MWCNTS/GCE sensor for detection of the ETO and also the experimental parameters such as film thickness, solution pH, time and accumulation potential were optimized. The obtained LOD of 1.6×10 −11 M is the lowest LOD, compared to LODs reported in the literature [31] for detection of ETO, using electrochemical techniques. This method was successfully applied for direct determination of ETO, and tested for human blood sample with high specificity, and sensitivity.