Open AccessAntidiabetic Activity of Triterpenoids from Anisophyllea disticha
Author(s) -
Miftahul Fikriyah,
Muhammad Almurdani,
Yum Eryanti,
Hilwan Yuda Teruna
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1655/1/012033
Subject(s) - acarbose , traditional medicine , triterpenoid , chemistry , triterpene , medicinal plants , ethyl acetate , solvent , diabetes mellitus , fractionation , chromatography , enzyme , medicine , organic chemistry , alternative medicine , pathology , endocrinology
Diabetes and its complication are strongly associated with mortality and morbidity rate in Indonesia. The number of diabetes patients is expected to increase every year. α-Glucosidase enzyme inhibitor widely used for treatment of diabetes. It may be obtained by isolation of Indonesian medicinal plants. As medicinal plant which is used by Talang Mamak tribe, Rakit Kulim, Indragiri Hulu, Riau, Anisophyllea disticha has its own attraction to study because its potential secondary metabolites have never been reported scientifically. Therefore, this study aims to determine antidiabetic activity by α-glucosidase inhibition method of metabolites this plant. The isolation of metabolites was based on solvent polarity fractionation by vacuum liquid chromatography method on ethyl acetate extract. Chemical structures of the metabolites were elucidated based on spectroscopic characteristics, included FTIR and 1D H-NMR. The isolated compounds were assumed to be two triterpene derivatives. The IC 50 of compound 1 , compound 2 , and acarbose as a positive control were 46.246 ± 0.166, 80.273 ± 0.08 and 19.737 ± 0.046, respectively. Therefore it can be concluded that both compounds have potential as antidiabetic.