Open AccessReview of CpG Island Recognition Algorithms
Author(s) -
Yanning Cai,
Qian Dong,
Anlan Li
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1624/4/042026
Subject(s) - epigenetics , cpg site , dna methylation , methylation , biology , genome , function (biology) , computer science , computational biology , dna , gene , algorithm , genetics , gene expression
DNA methylation is a common epigenetic process, which exists in many eukaryotes, such as animals and plants. It has the function of regulating gene expression and affecting the stability of genetic material. The unmethylated CpG dinucleotide, known as CGI, generally presents a local aggregation pattern in the genome. Abnormal methylation of CGI is often associated with cancer and abnormal growth. Therefore, it is of great significance to accurately identify CGI and predict its methylation state. This paper summarizes the current mainstream CGI computational recognition methods, analyzes their advantages and disadvantages, and discusses the future direction of CGI recognition algorithm research.