Open AccessDrug-attached magnetic nanoparticles: Locomotion control and in vivo biocompatibility
Author(s) -
Qian Xu,
Ruixue Yin,
Yuanxin Gu,
Hongbo Zhang,
Wenjun Zhang
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1549/3/032030
Subject(s) - biocompatibility , magnetic nanoparticles , in vivo , fourier transform infrared spectroscopy , nanoparticle , drug delivery , materials science , nanotechnology , biomedical engineering , drug , targeted drug delivery , nuclear chemistry , biophysics , chemistry , chemical engineering , pharmacology , medicine , microbiology and biotechnology , biology , engineering , metallurgy
Magnetic nanoparticles (MNPs) are playing an increasingly important role in the biomedical fields such as the diagnosis, treatment and monitoring of various diseases. Due to the unique properties of MNPs, MNPs with functionalized non-toxic surface coatings can be used for drug delivery in combination with therapeutic drugs or chemical molecules. A novel type of drug-attached magnetic nanoparticle was presented, where insulin was bound to magnetic Fe 3 O 4 nanoparticles (MNPs-Insulin). It was particularly proposed for the future in vivo control to realize the targeted locomotion. The properties of the MNPs-Insulin were characterized by Fourier-transform infrared spectra (FTIR), thermo gravimetric analysis (TGA) and vibrating sample magnetometer (VSM) analysis. The ability of magnetic control was tested in the local motion control system in vitro. The good biocompatibility was certificated by Hematoxylin-eosin staining (HE) on mouse.