Open AccessConventional vs Microwave assisted SiO2/P2O5 catalyzed synthesis of Schiff bases
Author(s) -
Neha Mishra,
Ritu Yadav,
K Shiva Kumar,
Hari Om Pandey,
Rajesh V. Pandey
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1504/1/012002
Subject(s) - isoniazid , benzaldehyde , yield (engineering) , catalysis , microwave , filtration (mathematics) , nuclear chemistry , chemistry , spectroscopy , derivative (finance) , materials science , combinatorial chemistry , organic chemistry , mathematics , computer science , tuberculosis , physics , medicine , telecommunications , statistics , pathology , quantum mechanics , metallurgy , economics , financial economics
Here in this work we have carried out synthesis of isoniazid and their benzaldehyde derivative in the presence of SiO 2 /P 2 O 5 catalyzed utilizing conventional and microwave assisted protocols. Both these protocols examined comparatively and we found that microwave assisted synthesis is more efficient, eco-friendly and economical method as compared to conventional method. Yield of product is also higher than conventional method. Use of heterogeneous catalyst is also promoting the yield of product and it is very easy to separate from the product by simple filtration and centrifugation. These synthesized compounds are characterized by physical and spectral studies (IR, UV-VIS, NMR spectroscopy) Isoniazid having excellent antitubercular activity and due to presence of Isoniazid they may have good antibiotic property.