Open AccessFlavonoid Derivatives from The Leaves of Muntingiacalabura L.
Author(s) -
Fera Kurniadewi,
Hanhan Dianhar,
Muktiningsih Nurjayadi,
Irma Ratna Kartika,
Dewi Khurun Aini
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1485/1/012030
Subject(s) - flavonoid , dpph , chemistry , ethyl acetate , antioxidant , fraction (chemistry) , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr , stereochemistry , organic chemistry
The Isolation and Purification of ethyl acetate fraction from Muntingiacalabura leaves have resulted three flavonoid derivatives. UV-Vis, 1 H-NMR dan 13 C-NMR data showed that isolate compounds are 2’,4’-dihydroxychalcone ( 1 ), 3,7-dimetoxy-5-hydroxyflavone ( 2 ), and 3,5,7-trihydroxy-8-methoxyflavone ( 3 ). The antioxidant evaluation against 2,2-diphenyl-1-picrylhydrazyl (DPPH), compound ( 3 ), showedto be a very high activity (IC 50 3,7 × 10 9 ppm). The isolated compounds were also evaluated for their cytotoxic activities against murine leukemia P-388 cells resulted that all isolated compounds were inactive.