Open AccessAcceleration of epithelialization in different application of scaffolds and growth factors post tooth extractions controlled by a mobile application
Author(s) -
Meta Maulida Damayanti,
Bethy S. Hernowo
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1469/1/012061
Subject(s) - fibrin , platelet rich plasma , platelet rich fibrin , wound healing , biomaterial , biomedical engineering , dentistry , platelet , extraction (chemistry) , medicine , chemistry , surgery , immunology , chromatography
Tissue engineering technology is widely used that involves the use of patients own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. Epithelialization is an essential component of wound healing used as a defining parameter of a successful wound closure. The purpose of this research was to analyse differences of wound healing process post tooth extraction between application of platelet-rich fibrin and platelet-rich plasma as a growth factors and hydroxyapatite as a scaffold seen from thickness of epithelialization. This research was an animal experiment. 18 rabbits randomly divided into 2 groups of treatment (K1) apply platelet-rich fibrin post tooth extraction and (K2) apply of platelet-rich plasma plus hydroxyapatite post tooth extraction. Then each treatment group was divided randomly into 3 groups of observation time (Day 3, 7 and 14). Tissue biopsy to see histopathologic pattern is analysed based on thickness of epithelialization. The results showed that thickness of epithelialization in group PRP+HA is similar with group PRF (P = 0.304). Thickness of epithelialization base on observation time had a significant difference in each group (P<0, 001). It was concluded that application of platelet-rich fibrin, platelet-rich plasma and hydroxyapatite can accelerate the wound healing of tooth extraction socket by means of thickness of epithelialization increasing.