Open AccessDevelopment of self nanoemulsifying drug delivery system for black seed oil (Nigella sativa L.)
Author(s) -
Sani Ega Priani,
Septiani Siti Maulidina,
Fitrianti Darusman,
Leni Purwanti,
Dina Mulyanti
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1469/1/012022
Subject(s) - bioavailability , pulmonary surfactant , drug delivery , chromatography , chemistry , peg 400 , materials science , chemical engineering , organic chemistry , pharmacology , medicine , biochemistry , polyethylene glycol , engineering
One strategy to improve oral bioavailability of hydrophobic drugs like black seed oil with formulate them into self nanoemulsifying drug delivery system (SNEDDS). The aim of this study is to develop black seed oil into liquid SNEDDS formulation to enhance oral bioavailability. The optimization of SNEDDS was carried out using various comparison between oil, surfactant and cosurfactant. The formulated SNEDDS were evaluated for transmittance percentage, emulsification time, dispersebility, robustness, thermodynamics stability and globul size determination. The best formulation of SNEDDS obtained from tween 80 as surfactan and PEG 400 as cosurfactant (2:1) with ratio of oil and mix surfactant-cosurfactant 1:8. The formulation of SNEDDS met the requirement of transmittance percentage (97.80%), emulsification time (35.00 second), grade A of dispersibility, stable of robustness and thermodynamic stability tests and the average of globul size was 65.4 nm. The SNEDDS formulation containing black seed oil has good physical characteristic and stability.