Open AccessSemi polar compounds from lemon-local: Focus on lipid metabolism
Author(s) -
Arief Budi Yulianti,
S I Raudina,
Rizki Amrulloh,
R. A. Retno Ekowati,
Annisa Rahmah Furqaani,
Maya Tejasari,
Miranti Kania Dewi
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1469/1/012017
Subject(s) - body weight , lipid metabolism , chemistry , cholesterol , total cholesterol , lipid profile , weight loss , zoology , medicine , endocrinology , obesity , biology , biochemistry
The study aim was analyzed the potential of semi polar compounds from lemon-local on old mice lipid profile with high fat dietary. Experimental study using DDY mice, males, 50−55 weeks. Five of 30 mice were sacrificed before treatment (group 6), group 1 (negative control), groups 2, 3, 4 and 5 were fed high fat dietary, group 3, 4 and 5 were treated doses 1, 2 and 3, respectively, orally. Parameters measured were body weight, HDL, TAG, total cholesterol. The results showed body weight of mice were above normal and dose 2 treatment cause weight loss (p=0.658). The highest cholesterol level was in positive control and the lowest was in the group given doses 2 (p=0.042). The highest triglycerides level was in the pretreatment group and the lowest was in the group given doses 2 (p=0.148). The highest HDL was in the positive group and the lowest was in the group given doses 2 (p=0.278). Semi polar compound from lemon-local at dose 2 could be regulated profile lipid on old mice with high fat dietary. This research needs to be improved, especially biomechanism of active substances.