Open AccessGlia-neuronal transitions in development: significance in medical research and treatment of pathologies
Author(s) -
Dmitrii Kamenev,
E. P. Kotsyuba,
Alexander V. Kalachev,
Valentin A. Milichko,
Vyacheslav Dyachuk
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1461/1/012101
Subject(s) - neuroscience , morphogenesis , homeostasis , autonomic nervous system , biology , autonomic ganglion , microbiology and biotechnology , gene , endocrinology , genetics , heart rate , blood pressure
The questions of how autonomic neurons and their fibers select the target organs and whether parasympathetic innervation affects the development and growth of diverse organs are still open. We hypothesize that glia-neuronal transitions in development is crucial for correct development and homeostasis of innervated tissues in mice. The result of this preliminary experiment using genetic tracing showed that the mice mutants with lack autonomic ganglia indeed have a problem with development of target organs and support idea that autonomic nervous system directly involved in innervated organs morphogenesis.