Open AccessPolymer capsules modified with iron oxide nanoparticles as an effective platform for MRI visualization and drug delivery
Author(s) -
Landysh Fatkhutdinova,
Anna Andreychenko,
Ekaterina Brui,
Alexander S. Timin,
Galina E. Pavlovskaya,
Andrei N. Khlobystov,
Mikhail V. Zyuzin
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1461/1/012037
Subject(s) - drug delivery , polymer , nanoparticle , magnetic resonance imaging , materials science , targeted drug delivery , nanotechnology , iron oxide nanoparticles , magnetic nanoparticles , drug , pharmacology , medicine , composite material , radiology
Efficiency of existing (usually toxic) drugs can be increased substantially with the targeted effect on the site of the disease. A potential platform for the targeted drug delivery can be polymer capsules. This will help reduce side effects on the human body and start treatment at the early stages of the disease. Modification of such capsules with the magnetic nanoparticles allows their visualization using magnetic resonance imaging (MRI). In this study the use of polymer microcapsules modified with iron oxide nanoparticles are employed as contrast agents for T 2 -weighted magnetic resonance (MR) images, the possibility of their implementation as for drug delivery carriers are discussed. For this, two different types of polymer capsules are synthesized. The results on the spin-spin and spin-lattice relaxivities were obtained.