Open AccessBiodistribution of 68Ga-DTPMP as a potential bone-seeking imaging agent in normal rats and rats with experimental model of bone callus
Author(s) -
В. К. Тищенко,
В. М. Петриев,
E. D. Stepchenkova,
A.V. Fedorova,
Andrey Postnov,
I. N. Zavestovskaya
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1439/1/012039
Subject(s) - biodistribution , femur , bone imaging , callus , nuclear medicine , chemistry , bone metastasis , positron emission tomography , medicine , pathology , cancer , metastasis , biology , in vitro , surgery , biochemistry , genetics
Bone metastases are common in advanced stages of various cancers. Positron emission tomography (PET) with radiotracers based on phosphonates and gallium-68 is a promising method of bone metastases detection. In this work a new complex based on diethylene triamine pentamethylene phosphonate (DTPMP) labeled with 68 Ga was developed and its biodistribution in normal Wistar rats and rats with experimental model of bone callus was studied. The biodistribution studies in normal rats revealed high skeletal uptake of 68 Ga-DTPMP (up to 1.45 %ID/g in femur) with rapid blood clearance and minimal uptake in any other major organs, except kidneys. In rats with experimental model of bone callus the accumulation of activity in bones and soft organs and tissues was slightly lower as compared with normal rats. The amount of 68 Ga-DTPMP in femur with bone callus was higher than in non-lesion bones and reached 1.90 %ID/g at 2 h p.i. Therefore, 68 Ga-DTPMP could be a promising radiotracer for bone tumors imaging and could be a valuable alternative to 18 F-FDG and 18 F-NaF for PET centers without an onsite cyclotron.