Open AccessPhotodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using photosensitizers based on octacationic derivatives of phthalocyanines and bacteriochlorins
Author(s) -
Г. А. Меерович,
E. V. Akhlyustina,
И. Г. Тиганова,
Е. А. Макарова,
Э. Р. Толордава,
Yu S. Zhizhimova,
N. I. Philipova,
Igor Romanishkin,
E. A. Luk’yanets,
Yulia M. Romanova,
Victor B. Loschenov
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1439/1/012036
Subject(s) - photodynamic therapy , pseudomonas aeruginosa , biofilm , photosensitizer , phthalocyanine , chemistry , microbiology and biotechnology , photochemistry , bacteria , biology , organic chemistry , genetics
Antibacterial photodynamic therapy is a promising method of treating local infected foci, especially surgical and burn wounds, trophic and diabetic ulcers. This work explores the photophysical and antibacterial properties of novel phthalocyanine- and synthetic-bacteriochlorin-based octacationic photosensitizers (PS). The results of the study confirm their low degree of aggregation at high concentrations, as well as high efficiency of photodynamic treatment of Gram-negative bacterial biofilms.