Open AccessStability of 131I-Ortho-Iodo-Hippuric Acid (131I-Hippuran) Labelled Compound Produced by CANST (Center of Applied Nuclear Science and Technology)-BATAN Bandung
Author(s) -
Endah Rosyidiah,
Titin Mulyati,
AW Teguh Hafiz,
Rizky Juwita Sugiharti,
Maula Eka Sriyani
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1436/1/012060
Subject(s) - hippuric acid , chemistry , radiochemistry , chromatography , nuclear medicine , medicine , urine , biochemistry
131 I-ortho-iodo-hippuiic acid ( 131 -Hippuran) labelled compound has been used in nuclear medicine for renal function evaluation. The labelled compound solution administered to patients via intravenous injection. Radiation from the labelled compound tracked by gamma detector in Renograph. PSTNT has succeeded produce 131 -Hippuran to cover the demand from An Nur Urology-Specialized Hospital, Yogyakarta. 131 -Hippuran was purified by column chromatography method. HPLC analysis were performed to specified which fraction has higher radiochemical purity and will be used for patients. 131 -Hippuran stability testing needs to be done related to the decay of radioactive compounds. Three storage temperatures were prepared as follows: 4, 25, and 30 th C. Radiochemical purity of each temperature determined by paper electrophoresis method on day 1, 6, 9, 13, 20, 23, and 30. The static phase used was whatman 1 paper, while mobile phase was phosphate buffer pH 9. The initial radiochemical purity is 99.52%. While on 30” day, radiochemical purity in storage temperatures of 4, 25, and 30°C are 97.04, 96.37, and 96.96% respectively. Statistical analysis using SPSS was performed to determine whether there was a significant difference in the radiochemical purity of each storage temperature. Normality and homogeneity test showed the radiochemical purity is normally distributed and has homogenous variance at three different storage temperature. Furthermore, the result of One-way ANOVA test showed that there was no significant difference of radiochemical purity in various storage temperatures. In conclusion, 131 -Hippuran labelled compound produced by CANST-BATAN Bandung is relatively stable up to 30 days and not affected by storage temperature.