Open AccessBase damages induced in DNA by 10 eV electrons: contribution to the radiosensitization mechanism of platinum chemotherapeutic drugs
Author(s) -
W. Liu,
Yujie Gao,
V. Lemelin,
Yi Zheng,
L. Sanche
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1412/20/202004
Subject(s) - dna , mechanism (biology) , damages , dna damage , electron , chemistry , biophysics , cancer research , medicine , biology , biochemistry , physics , political science , quantum mechanics , law
Synopsis Binding of Pt-drugs to DNA significantly enhaces base damages, crosslinks, double strand breaks (DSBs) and non-DSB cluster lesions induced by 10 eV electrons. This enhancement of potentially lethal lesions is due to a modification of electron-DNA interactions, which contributes to the synergy between chemo- and radio-therapy, when these modalities are administered in concomitance during cancer treatments.