Open AccessInfluence of ionizing radiation on molecular recognition in the gas phase: VUV and X-ray photoabsorption of antibiotic-receptor non-covalent complexes
Author(s) -
Marwa Abdelmouleh,
Mathieu Lalande,
Alejándro Rodríguez,
Violaine Vizcaino,
Jimmy Rangama,
Thomas Schlathölter,
JeanChristophe Poully
Publication year - 2020
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1412/15/152061
Subject(s) - ionizing radiation , covalent bond , protonation , synchrotron radiation , intramolecular force , chemistry , deprotonation , atomic physics , irradiation , physics , nuclear physics , ion , stereochemistry , organic chemistry
Synopsis The intrinsic effects of ionizing radiation on molecular recognition between an antibiotic and its re-ceptor have been probed by coupling a synchrotron beamline to a tandem mass spectrometer. Protonated vanco-mycin-receptor non-covalent complexes in the gas phase undergo inter-as well as intramolecular bond cleavage due to internal energy transfer after photoabsorption in the VUV-X energy range. The deprotonated complex undergoes electron detachment, but the native interactions underlying molecular recognition are not systematically lost.