Open AccessKurzichalcolactone A and B, two chalcone derivatives from Indonesian Cryptocarya
Author(s) -
Fera Kurniadewi,
Muktiningsih Nurjayadi,
Irma Ratna Kartika,
Euis Holisotan Hakim,
Lia Dewi Juliawaty,
Yana Maolana Syah
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1402/5/055081
Subject(s) - chalcone , indonesian , chemistry , stereochemistry , leukemia , biology , genetics , philosophy , linguistics
Kurzichalcolactone A ( 1 ) and B ( 2 ), two chalcone derivatives were isolated from two species of Indonesian Cryptocarya : Cryptocarya phoebeopsis and Cryptocarya morotaiense . The structures of the isolated compounds were elucidated based on the analysis of spectroscopic data, including UV, IR, NMR, and mass spectra. On biological evaluation of these compounds for their cytotoxic activity, it was found that ( 1 ) exhibited moderate inhibition activities against murine leukemia P388 cells while ( 2 ) was inactive.