Open AccessOptimization of Dual Pathway AV Nodal Conduction Model
Author(s) -
M. Ryzhii,
Elena Ryzhii
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1372/1/012078
Subject(s) - reentry , node (physics) , atrioventricular node , refractory period , computer science , nodal , automaticity , effective refractory period , electrical conduction system of the heart , topology (electrical circuits) , dual (grammatical number) , nonlinear system , function (biology) , mathematics , cardiology , electrocardiography , physics , medicine , neuroscience , biology , art , cognition , literature , quantum mechanics , combinatorics , evolutionary biology , tachycardia
In this work we tested our previously proposed heterogeneous oscillator model of atrioventricular node with respect to dual pathway physiology in order to optimize the model parameters. For this purpose we compared three model variants with different number of pathway node elements represented by nonlinear Aliev-Panfilov equations. The parameters controlling coupling between the pathway elements and the refractoriness of the fast pathway were selected for each model variant to obtain qualitative correspondence to the all range of functional atrioventricular node behavior. The results demonstrate that all considered model variants are able to reproduce normal cardiac signals conduction, AV node reentry, automaticity (pacemaking) and filtering function. However, the model variant with smallest number of the pathway elements better correspond to human electrophysiology, in particular to filtering high atrial rates by AV node. In addition, it is preferred for use in low-power systems with real-time simulations, such as ICD and pacemaker validation and testing hardware, as well as for educational and research purposes.