Open AccessAnti coagulant activities of Brown Seaweed Sargassum cristaefolium Extract
Author(s) -
Marianti A. Manggau,
M. Guntur Hamzah,
Sukamto S. Mamada,
Wira Bahari Nurdin,
EN Zaenuddin
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1341/7/072006
Subject(s) - sargassum , prothrombin time , partial thromboplastin time , clotting time , brown algae , brown seaweed , traditional medicine , blood clotting , thromboplastin , in vivo , algae , flavonoid , chemistry , coagulation , botany , biology , medicine , biochemistry , microbiology and biotechnology , antioxidant
Brown algae, Sargassum cristaefolium is grown abundant in Indonesia especially in South Sulawesi Province. In vitro anticoagulant effect of the extract has been shown. Therefore a study of Sargassum cristaefolium, used to inhibit blood coagulation in vivo was done. In this study, effect of flavonoid compounds from Sargassum cristaefoilum to elongate bleeding and blood clotting time and also (Prothrombin Time (PT) and Activated Thromboplastin Time (APTT) tests were carried out. Moreover, histology of mice stomach was also studied. From this study we found, that effect on bleeding time after 14 days treatment of Sargassum extract in vivo prolonged the clotting and bleeding time significantly (p < 0.05). Prothrombin time (PT) and activated partial thromboplastin time (APTT) tests on plasma confirm these research. From this study we conclude, that the flavonoid compound in Sargassum cristaefolium exhibited an anticoagulant activity.