Open AccessThe Potency Study of Organotin(IV) 3-Nitrobenzoate Compounds as Antimalarial Agents
Author(s) -
Sutopo Hadi,
Noviany,
Hardoko Insan Qudus,
Pakorn Wattana-Amorn
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1338/1/012012
Subject(s) - chemistry , potency , antimalarial agent , stereochemistry , medicinal chemistry , chloroquine , in vitro , malaria , biochemistry , immunology , biology
This paper reports the potency study of organotin(IV) 3-nitrobenzoate as antimalarial agent. The organotin(IV) 3-nitrobenzoate compounds were synthesized by reacting the intermediate products dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, with 3-nitrobenzoic acid. The antimalarial activity study was performed against Plasmodium falcifarum and the result of IC 50 of the three compounds tested, i.e. dibutyltin(IV) di-3-nitrobenzoate, diphenyltinIV) di-3-nitrobenzoate and triphenyltin(IV) 3-nitrobenzoate were 8.1 x 10 −3 , 5.2 x 10 −2 and 7.2 x 10 −3 µg/mL, respectively, while the the chloroquine gave IC 50 2 x 10 −3 µg/mL). The IC 50 of the compounds tested were little bit higher than the positive control, however these organotin(IV) compounds synthesized are not resistent to Plasmodium, thus the possible development as antimalarial agent is widely opened.