Open AccessSynthesis 4-Piperoilmorpholine from Piperine
Author(s) -
Shamshul Bahri,
Yuli Ambarwati,
Morshed S. M. Iqbal,
A. A. Baihaqy
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1338/1/012010
Subject(s) - piperine , morpholine , chemistry , yield (engineering) , hydrolysis , solvent , pepper , ethanol , chromatography , nuclear chemistry , organic chemistry , materials science , food science , metallurgy
Piperine was isolated from black pepper by soxhletation method using technical grade ethanol as a solvent. This compound was used as precursor for the synthesis of 4-piperoilmorpholine. The synthesis was carried out via a pre-target piperoilchloride, where the piperine was initially hydrolyzed using KOH ethanolate for 24 hours, added SOCl 2 and then mixed with morpholine at 0-5° C. The result of synthesis was obtained 4-piperoilmorpholine with yield of 40,80%.