Open AccessThe sirangak (cyanthillium cinereum; asteraceae) oil accelerates sliced-wound healing by enhanching the hematological endurance in male albino mice
Author(s) -
Muhammad Rahmanda Fadillah,
Putra Santoso
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1317/1/012080
Subject(s) - wound healing , hemoglobin , mean corpuscular hemoglobin concentration , traditional medicine , essential oil , mean corpuscular volume , medicine , physiology , pharmacology , biology , surgery , botany
Sirangak ( Cyanthillium cinereum ; Asteraceae) is a medicinal plant traditionally used by Minangkabaunese, West Sumatra to heal the wounds. However, the underlying mechanism of this plant in healing the wounds is scientifically unelucidated. This current research aimed to clarify that Sirangak could potently accelerate the wound healing by enhanching the hematological performances. We conducted an experiment by using adult male mice consisted of control group and Sirangak oil-topical treated group after being wounded by superficial slice cuting. Subsequently, the wound healing rate was determined and the hematological profiles were monitored periodically for a week. The results demonstrated that Sirangak oil could significantly accelerate the wound healing by 85.6% as compared to control with a 71.6% of wound recovery. The hematological analysis indicated that Sirangak oil could significantly increase the erythrocyte count, hemoglobin concentration, hematocrite, mean cell volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) particularly during the early day of treatment. However, Sirangak oil did not significantly affect the leucocyte profiles except for the granulocyte. Therefore, the Sirangak oil could potently accelerate wound healing by enhanching the physiological endurance particularly the erythrocyte and hemoglobin level. This finding underpins a scientific evidence for further use of Sirangak in medicine.