Open AccessSynthesis, Characterization, and Antibacterial activity of some new Bis β-Lactam Derivatives from Folic acid
Author(s) -
Eman Abdul wahab Alkuwaity,
Zeyad Kadhim Oleiwi
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1294/5/052076
Subject(s) - lactam , chemistry , folic acid , antibacterial activity , tyrosine , tryptophan , histidine , ethanol , organic chemistry , stereochemistry , amino acid , bacteria , biochemistry , medicine , biology , genetics
Firstly, two Schiff bases have been prepared by condensation reaction of folic acid with (4-chloroacetophenone and 4-hydroxyacetophenone) in ethanol. Then the resultant compounds (1,2) react with another Schiff bases by reacting of 4-bromobenzaldehyde with an amino acid (Phenylalanine, Tryptophan, Tyrosine, and Histidine) to give bis-β-lactam rings. The structures of target compounds were characterized by many spectroscopic methods including NMR, FTIR technique and their melting points. The β- lactam derivatives were checked and examined for antibacterial activity.