Open AccessSchiff base – Cyclodextrins inclusion complexes
Author(s) -
Jabbar S. Hadi,
Ayat Abdul-Kadhim
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1294/5/052057
Subject(s) - schiff base , solubility , solubilization , condensation , chemistry , base (topology) , nuclear chemistry , organic chemistry , polymer chemistry , mathematics , biochemistry , thermodynamics , physics , mathematical analysis
A Schiff base derived from the condensation ofr indole-3-carboxaldehyde with sulfathiazole wase prepared, and used to prepare three inclusion complexes with β-CD, 2HP-β-CD and 2HP-γ-CD by freeze drying method, the formation of Schiff base and the nature of interaction with CDs were confirmed by IR, HNMR and XRD. The phase solubility of Schiff base in β-CD and 2HP-β-CD were studied following Higuchi and Connors method, the stability constant value of complexes and the solubilization efficiency were estimated.