Open AccessSynthesis, characterazition of some 2-mercapto-5-methoxy-1H-benzimidazole and test with some plant pathogenic fungi
Author(s) -
Ihmood Kh. Jebur,
Salih Mohammed Ismail
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1294/5/052034
Subject(s) - rhizoctonia solani , benzimidazole , benzothiazole , fusarium oxysporum , potassium hydroxide , nuclear chemistry , chemistry , ethanol , proton nmr , organic chemistry , medicinal chemistry , stereochemistry , biology , botany
In this research the new starting material 2-mercapto-5-methoxy-1H-benzimidazole (S1) was synthesized by the condensation reaction of 4-methoxy-o-phenylenediamine and (1mmol) and carbon disulfide (1 mmol) in ethanol (10 mL) under basic condition we used potassium hydroxide as base which produced MBI with high yield and purity. 2-mercapto-6-methoxy-1H-benzimidazole(S1), which on treatment with hydrazinehydrate in ethanol yielded hydrazino-6-methoxy-2-mercapto benzothiazole ( S2 ).Condensation of compound (S2) with 4-(N,N-di Methylbenzaldehyde yielded 4-[(N,N-di Methyl bezylidine) hydrazino)]- 6-methoxy -2-mercaptobenzothiazole ( S3 ).The synthesized compounds were identified according to their physical properties, spectroscopic data (FT-IR, 1 H-NMR, and 13 C-NMR) The study showed three chemical compounds test S1, S2, and S3 to three concentration (100, 200, 300) mg/L.in inhibiting colony diameter of three phytopathoginc fungi Fusarium oxysporum fsp.watermilon,Macro phomina phasiolina and Rhizoctonia solani these compounds effectiveness of inhibition of S1 and to three concentrations of the high against growth of fungi, with an inhibitory rate of 89.39% While S2 was less effective at inhibition of 33.89%.