Open AccessSynthesis, Characterization and study biological activity of some Schiff bases derivatives from 4-amino antipyrine as a starting material.
Author(s) -
Hutham Mahmood Yousif Al-Labban,
Hawraa Mohammed Sadiq,
Ahmed Abduljabbar Jaloob Aljanaby
Publication year - 2019
Publication title -
journal of physics. conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1294/5/052007
Subject(s) - benzaldehyde , chemistry , antibacterial activity , schiff base , toluene , thin layer chromatography , solvent , ethyl acetate , derivative (finance) , agar diffusion test , ethanol , organic chemistry , nuclear chemistry , chromatography , bacteria , catalysis , stereochemistry , escherichia coli , biochemistry , biology , financial economics , economics , genetics , gene
This study includes formation Schiff bases compounds [A 1- A 3 ] were synthesis from raction4-aminoantipyrine with many aromatic aldehydes [4- chloro benzaldehyde, 4-bromo benzaldehyde and 2-hydroxy1-naphthaldehyde] in absolute ethanol. These compounds [A 1 -A 3 ] has been characterized by melting points, [FT.IR] spectroscopy, thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent (ethyl acetate:toluene, 1:4). Antibacterial activity test was done according to agar well diffusion method against two types of multi-drug resistance of bacteria isolated from patients with infection of urinary tract. Three concentrations were prepared for each compound (50, 100 and 150) mg/ml. The results proved that derivative compound A 3 150 mg/ml provided the best antibacterial activity against K.pneumoniae with inhibition zone diameter 21± 0.25mm and against C.freundii 22± 0.5mm as compared with other derivatives compounds.